Guide to PubMed

PubMed is a database of resources, primarily journal articles, in the health sciences and life sciences. As of July 2019, it contains over 29 million citations, and new citations are continuously added as papers are published. Although PubMed does not contain the full-text of articles or books, it does link to them. Most are either publicly accessible through PubMed Central or available via Rice University library subscriptions. (For information about accessing the full text of articles, see here.)

 

This guide covers:

 

 

For a brief overview of PubMed searches, see this tutorial.

Link PubMed and Fondren

To access materials in PubMed that aren’t publicly available, you’ll need to make sure PubMed is linked to Fondren so you can access the library’s subscriptions. This should happen automatically on-campus, but you’ll have to connect PubMed and Fondren yourself off-campus. The library’s link to PubMed can be found here. The link can also be accessed by searching for PubMed underneath the databases tab on the library’s homepage and following the link in the search results.

Screenshot of Fondren's homepage with the "Databases" tab open and boxed in red.
Screenshot of an A-Z Databases search for PubMed with the link to PubMed boxed in red.

It’s also a good idea to make sure you have Google Scholar linked to Fondren. This ensures the most seamless access to resources possible.

Sometimes, you still won’t be able to access a resource you need because Fondren doesn’t subscribe to the journal, or doesn’t have access to a particular year of a journal. In these cases, you’ll need to place an interlibrary loan request.

Access Full Text

When you find a useful article, click on it. PubMed does not store the full text of articles, but links to the full text will be available on the right side of the article’s page.

Screenshot of an article record in PubMed with full text links boxed in red.

Options to access the article’s full text will vary. Some will have several options. If the journal has published the article open access, or the article has been deposited into PubMed Central, links to those free copies of the article will appear.

Screenshot of the full text links for a PubMed article with the free versions boxed in red.

In these cases, simply clicking on the journal or PubMed Central link will take you directly to the article.

Screenshot of a PubMed Central copy of an article titled "Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8- T-Cell Receptor Repertoires."

Other times, the only option to access the article’s full text will be through Rice’s library resources. This is why it’s important to make sure PubMed is linked to the library.

Screenshot of the full text links for a PubMed article with only Rice Full Text appearing.

Clicking the Rice Full Text icon will take you to a list of access options. Click one to be taken to the article itself.

Screenshot of a list of Fondren access options for an article with the "Go" button of the top option boxed in red.
Screenshot of an article titled "Vein of Marshall ethanol infusion for persistent atrial fibrillation."

The Rice Full Text icon will appear even if the library does not have access to that particular article. In these cases, you will be directed to place an interlibrary loan request to access the item. You can read more about interlibrary loan here.

Screenshot of a link to submit an interlibrary loan request.

Search PubMed

Basic Search

 

A good way to start searches in PubMed is with keywords, the same way you would in the library’s OneSearch or Google Scholar. Keywords can be conditions, symptoms, chemicals or drugs, or any other concept in the medical literature you want material on. By default, results are sorted by most recent.

Screenshot of a PubMed search for "stem cells" with the search boxed in red.

However, because PubMed is such a large database, try to be specific when conducting keyword searches. The above search for “stem cells” returns over 300,000 results. Adding the keyword “dental pulp” to the search narrows the results to 2,400. You can use Boolean operators in PubMed keyword searches, but avoid filler words like “the,” “in,” and such.

Screenshot of PubMed search for "dental pulp stem cells" with the search and number of results boxed in red.

If your search isn’t returning the results you expect, scroll down to the “Search details” box on the right side of the search results. PubMed automatically matches your keywords to its subject headings (called MeSH for Medical Subject Headings).

 

For this search, PubMed correctly linked the keywords to the “dental pulp” and “stem cells” subject headings, but in cases where your keywords and the subject headings don’t match, there may be errors, and you may want to rephrase your search.

Author Search

You can use PubMed’s main search bar to search for materials by a particular author. PubMed does not list authors’ first names, so the most efficient way to search for an author is the format “LastName Initial(s).” 

Whether you want to search with one or two initials depends on how common the author’s last name is. The following search is for Dr. Martin J. Citardi, the chair of the otorhinolaryngology department at McGovern Medical School. The search uses one initial and produces a manageable number of results, the first several of which are clearly in Dr. Citardi’s field and thus probably authored by him and not another researcher with the name last name and first initial.

Journals don’t always include authors’ middle initials, so searching only an author’s first initial guarantees your results include every publication by that author indexed in PubMed.

Screenshot of a PubMed search for "Citardi M" with the search and number of results boxed in red.

The next example search is for Dr. Zi Yang Jiang, an assistant professor in the same department at McGovern. However, Dr. Jiang has a much more common last name, and a search for “Jiang Z” produces over 9,000 results. In this case, including Dr. Jiang’s middle initial is necessary. The number of results is still fairly high, but is much more practical to scroll through and scan for articles in Dr. Jiang’s field than the original number is.

Screenshot of a PubMed search for "Jiang Z" with the search and number of results boxed in red.
Screenshot of a PubMed search for "Jiang ZY" with the search and number of results boxed in red.

Journal Search

You can also use PubMed’s homepage search bar to search for journals. These searches will return articles from a particular journal, not links to the actual journals. Journals can be searched for by full title or abbreviation, as shown below.

Screenshot of a PubMed search for "annals of the rheumatic diseases" with the search and number of results boxed in red.
Screenshot of a PubMed search for "ann rheum dis" with the search and the number of results boxed in red.

Searches for journal abbreviations may return more results. Usually, this is because articles from other journals had terms matching words in the abbreviation in their titles, keywords, or abstracts.

Advanced Search

PubMed’s advanced search function can be accessed from the homepage.

Screenshot of the search bar on PubMed's homepage with "Advanced" boxed in red.

Advanced search allows you to search within a wide variety of fields, including author affiliation, author names, dates, grant numbers, journals, languages, subject headings (MeSH), pharmacological actions, titles, and more. If you have more than one advanced search term, they must be joined by a Boolean operator.

Screenshot of the top of "All Fields" drop-down menu in PubMed's advanced search.
Screenshot of the bottom of the "All Fields" drop-down menu in PubMed's advanced search.
Screenshot of the "AND" drop-down menu in PubMed's advanced search.

Additionally, you can rerun previous searches in advanced search by scrolling down and accessing your search history.

Screenshot of a blank search history on PubMed's advanced search page.

For some fields in advanced search, such as Journal, suggestions will appear as you type. Selecting a suggestion will make sure PubMed recognizes the term you enter.

Screenshot of a suggested search for the Journal field in PubMed's advanced search.

PubMed automatically adds blank fields as you fill out the form. Don’t worry about an extra blank field; they are disregarded when you search.

Screenshot of an advanced search for "The Journal of heart and lung transplantation" and "psychology" filled out in PubMed's advanced search.
Screenshot of the search results for the previously described PubMed advanced search.

Refine Results

Like other databases and OneSearch, PubMed has a variety of options for refining search results. By default, PubMed only shows filters for Article types, Text availability, Publication dates, and Species. Clicking “Show additional filters” beneath the others will allow you to select other filters, such as languages, subjects, or the age or sex the study concerns.

Screenshot of the default search results filters in PubMed.
Screenshot of additional available filters in PubMed with "Show additional filters" boxed in red.

Some filters can be customized by clicking “Customize…” or “Custom range…” at the end of their default list. Shown below are the customization options for Article types, which allows you to select from a wide variety of article formats and study types, and Publication dates, which allows you to set your own range of dates.

Screenshot of the "Article types" filter menu in PubMed.
Screenshot of the "Custom date range" function in PubMed.

The following images show a search for “splenectomy” that is then refined to show only results published in the last five years that focus on the procedure in adolescents.

Screenshot of a PubMed search for "splenectomy" with the number of search results boxed in red.

To refine results to materials about adolescents, the age filter must be added and then customized.

Screenshot of the "Show additional filters" menu in PubMed with "Ages checked and boxed in red.
Screenshot of the "Customize..." menu for the PubMed Ages filter with "Adolescent: 13-18 years" checked and boxed in red.

With the appropriate filters applied–for publication date in the last five years, for humans, and for adolescents–the number of results drops from over 29,000 to 346.

Screenshot of a PubMed search for "splenectomy" with Publication dates, Species, and Ages filters applied with the filters and number of results boxed in red.

Review Articles

Articles in PubMed generally fall into one of two types:

 

Primary research articles:

These articles are specific reports on a study and include methodology. They are often just called “articles” or “papers.”

 

Review articles:

These articles summarize recent research on a particular subject, using the findings of multiple primary research articles.

 

Review articles are useful for:

 

  • An introduction to a new topic
  • A source for citations of relevant primary research

 

To access review articles, search like you normally would, then select “Review” under the “Article types” filter.

Screenshot of a PubMed search for "'hemophilia A' AND 'gene therapy'" with the search and the number of results boxed in red.

Applying the “Review” filter under “Article types” and the “5 years” filter to “Publication dates” limits the number of results to 75. The results are sorted by most recent, but for a search like this one for review articles, looking at the “Best matches” at the top of the results may be helpful, too.

Screenshot of a PubMed search for "'hemophilia A' and 'gene therapy'" with the search, the number of results, the applied filters, and the suggested best matches boxed in red.

Medical Subject Headings

PubMed’s articles are indexed with Medical Subject Headings (MeSH). Subject headings in general are discussed here. You can use MeSH terms to construct more precise searches than with basic keyword searches, and to capture more results when the topic you’re searching is known by multiple names.

 

However, it’s important to remember that MeSH terms are assigned by people, and this takes time. As such, most articles in PubMed don’t receive MeSH terms until about a year after their publication. Keyword searches won’t produce results as precise, but they will be the most recent. Keywords and MeSH terms can be combined so that recent publications are included in the search.

Finding MeSH Terms

To search for relevant MeSH terms, open the drop-down menu on the homepage search bar and change “PubMed” to “MeSH.”

Screenshot of the drop-down menu for PubMed's homepage search bar with "MeSH" boxed in red.

Type your term. Some terms will automatically match to a MeSH term, but less specific terms will lead to a list of potentially relevant MeSH terms.

Screenshot of a MeSH search for "anemia" with the top result boxed in red.

Once you click on a relevant term, you can scroll down to see other MeSH terms related to that one. MeSH terms are arranged so that more specific terms will appear below a term, and broader ones above it. By default, PubMed searches for all of the more specific terms beneath a term.

Clicking on “All MeSH Categories” will lead to the main list of MeSH terms.

Screenshot of a MeSH term tree for Anemia with "Anemia" and "All MeSH Categories" boxed in red.
Screenshot of a list of all MeSH categories.

As is shown above, MeSH categories don’t only cover diseases and conditions. They also cover diagnostic tests, therapies, medical equipment, anatomy, chemicals and drugs, health occupations, geographical locations, individual people, pharmacological actions, biomedical phenomena, psychology, publication types, and more.

Searching with MeSH Terms

A phrase search for “heart attack” only returns about 4,000 results. Since cardiac disease is the most common cause of death in the United States, this is far fewer articles than one would expect to be about heart attacks.

Screenshot of a PubMed phrase search for "heart attack" with the search and the number of results boxed in red.

A MeSH search for “heart attack” leads directy to the MeSH page for “myocardial infarction.” On the right of the page, click “Add to search builder” underneath the PubMed Search Builder box to search with the MeSH term.

Screenshot of the MeSH page for myocardial infarction with the search box and page title boxed in red.
Screenshot of a PubMed Search Builder with the MeSH term "myocardial infarction" added and the "Add to search builder" button boxed in red.

A search using the MeSH term retrieves nearly 170,000 results, which makes more sense for the topic’s importance. However, as mentioned earlier, the most recent articles won’t have the “myocardial infarction” MeSH term assigned to them yet, so combining this search with related keywords–like the phrases “heart attack” and “myocardial infarction” without the MeSH specifier–might be a good idea.

Screenshot of a PubMed search for the MeSH term "myocardial infarction" with the search and number of results boxed in red.

Subheadings

Subheadings can be added to MeSH terms to combine two concepts in your searches. For example, let’s say you want to search for the use of chiropractic treatment for animals. First, a MeSH search for “chiropractic adjustment” automatically directs to “Manipulation, Chiropractic.”

Screenshot of the MeSH page for "Manipulation, Chiropractic" with the search bar and page title boxed in red.

The subheadings that apply to this term appear in columns. One is “veterinary,” and that will restrict our search to chiropractic manipulation in veterinary care. Checking “Restrict to MeSH Major Topic” is also a good idea, so articles that only briefly touch on the topic will be excluded.

If there were more specific MeSH terms underneath chiropractic manipulation (it so happens that there aren’t), and we didn’t want to see results about those more specific topics, we could check “Do not include MeSH terms found below this term in the MeSH hierarchy.”

Screenshot of the MeSH page for "Manipulation, Chiropractic" with the veterinary subheading and "Restrict to MeSH Major Topic" box checked.
Screenshot of a PubMed Search Builder with the major topic "Manipulation, Chiropractic/veterinary" added and the "Add to search builder" button boxed on red.

The results of search are shown below. The number is fairly limited. This may be because the topic has been categorized under several different MeSH terms, or it may be because the topic is very niche. Sometimes, trying several related searches can help you determine if your topic is highly specialized, or if there is material you missed originally.

Screenshot of a PubMed major topic search for "Manipulation, Chiropractic/veterinary" with the search boxed in red.

Additional PubMed Features

Citation Matcher

 

PubMed offers a citation matcher search that allows you to search for items you have a citation for. For example, let’s say someone recommended you read an article called “Recent advances in biosensor for detection of lung cancer biomarkers,” published by Yang et. al. in Bionsensors and Bioelectronics.

 

First, access the citation matcher from underneath “PubMed Tools” on the homepage.

Screenshot of the PubMed homepage with "Single Citation Matcher" under "PubMed Tools" boxed in red.

Next, fill in as many of the fields in the citation search as you can. If only one article matches the information you entered, you will be taken directly to it. Otherwise, you will see a list of potential matches or, if nothing matches, an error.

Screenshot of a PubMed Single Citation matcher form with the journal, author name, and title words fields filled out.
Screenshot of the search result for the Single Citation Matcher form filled out above.

Topic-Specific Queries

 

PubMed has constructed several searches that relate to particular topics. These include comparative effectiveness research, AIDS, cancer, complementary medicine, health disparities, health literacy, toxicology, and more, as well as selected sets of core clinical, dental, and nursing journals. The list of topics and links to apply the search strategies can be found here.

 

First, access the links to topic-specific searches by clicking “Topic-Specific Queries” under “PubMed Tools” on the homepage.

Screenshot of the PubMed homepage with "Topic-Specific Queries" underneath "PubMed Tools" boxed in red.

Next, browse the list of topics until you find one you want. Keep in mind that while these searches are useful and help retrieve more searches than you might otherwise, not every topic has a search here. Click the name of the search to activate it.

Screenshot of part of the special queries menu in PubMed with "AIDS" boxed in red.

When a search has been activated, a notice of its application will appear on the PubMed homepage. The search will be applied to ALL searches until “Clear all” is clicked. It will NOT automatically remove itself.

Screenshot of the PubMed homepage with the AIDS special filter applied and the notice boxed in red.

With the filter applied, run your search as you normally would. You can search for a keyword to see results that pertain both to that keyword and your chosen subject, or apply a MeSH term relevant to what you want to find. The following example shows a search for the MeSH term for the Midwestern United States with the AIDS search filter applied.

Screenshot of a PubMed search for the "Midwestern United States" with the AIDS search filter applied and the search and the filter notice boxed in red.

Clinical Queries

 

PubMed has a search interface that allows you to search only for materials that have clinical relevance. These searches will exclude, for example, basic sciences studies and studies about epidemiology or trends. The clinical queries search can be found here.

PubMed divides clinically relevant materials into three categories:

 

  • Clinical Study: articles about studies done on questions related to the etiology, diagnosis, therapy, and prognosis of clinical problems, such as controlled trials and case reports.
  • Systematic Reviews: articles that summarize all available evidence on a clinical question.
  • Medical Genetics: articles that discuss the genetic components of a clinical issue, including diagnosis, management, and genetic testing.

 

First, access the clinical queries search by clicking “Clinical Queries” underneath “PubMed Tools” on the homepage.

Screenshot of the PubMed homepage with "Clinical Queries" underneath "PubMed Tools" boxed in red.

Next, search for a keyword or keywords. Relevant studies will appear in columns underneath the appropriate study type.

Screenshot of the PubMed Clinical Queries search page.

After you search, you’re able to choose the category and scope (broad or narrow) of clinical studies, as well as the topic of medical genetics articles.

Screenshot of a PubMed Clinical Queries search for "kidney stones" with the Category drop-down menu for clinical studies open.

Export Search Results

 

To save the results of a search, click “Send to” on the right side above the results list. “File” will create a text file detailing the results, while “Citation manager” allows you to export results to Zotero or another citation manager, and “Email” allows you to email the results to yourself or somebody else.

Screenshot of a PubMed search for "fungal sinusitis" with the "Send to" function open and boxed in red.

Find Related Articles

Click on an article you’re interested in to see related articles. On the right side of the article’s page, PubMed lists “Similar articles,” which cover the same or a closely related topic, and below that is a list of articles in PubMed Central that cite the article.

 

Not every article is deposited in PubMed Central. Checking the “Cited by” section can be useful for finding newer articles on the topic, but it is not a citation search.

Screenshot of the "Similar articles" and "Cited by" lists for a PubMed article about ginseng.

PubMed for Handhelds

PubMed has a mobile-optimized interface, called PubMed for Handhelds. Note that not all features are available, so you’ll want to use the full web version when possible.

Screenshot of MEDLINE/PubMED for Handhelds.

More Biomedical Information Resources

PubMed isn’t the only place to find biomedical information. Sometimes, if your search is specific, or if you’re searching a basic science topic, other resources may provide more relevant results. Other times, you may check a few different resources to make sure you’ve found as much as you can.

More Databases

Academic Search Complete

Academic Search Complete covers scholarly and general interest resources in medicine, science, social sciences, and other fields. May be too general for some searches. Academic Search Complete mobile interface here.

 

Alt Health Watch

Alt Health Watch covers a wide variety of topics and access to peer-reviewed journals in the fields of complementary and alternative medicine. Alt Health Watch mobile interface here.

 

American Health Line

American Health Line provides daily, nonpartisan coverage of current public policy and industry news related to medicine and healthcare.

 

Biological Abstracts

Biological Abstracts indexes over 5,000 international journals in the life sciences, including genetics, medicine, pharmacology, biochemistry, biotechnology, and more. Note: Access is limited to 10 simultaneous users.

Drug Information Portal

The Drug Information Portal is a search tool from the NIH that searches multiple resources for information on drugs and supplements, including PubMed, DailyMed (a database of manufacturer labels), clinicaltrials.gov, and more.

 

MEDLINE

MEDLINE is a subset of the resources indexed in PubMed. MEDLINE includes citations for over 5,000 peer-reviewed journals selected by committee and is limited to journal articles. If PubMed’s results are too broad, using MEDLINE may help narrow them. MEDLINE mobile interface here.

 

Merck Manuals

Merck Manuals are free databases of biomedical information. They include thousands of health-related topics, how-to videos, animations and photos, self-assessment tools, clinical calculators, 3D models, news, and more. Available in professional, consumer, and veterinary versions.

PsycINFO

PsycINFO indexes literature related to psychology and related fields. A good resource for information on psychiatry and mental health. 

 

PubChem

PubChem is a free database containing information over 200 million chemical substances. You can search for chemicals by name or compound, and topics covered include chemical structure and properties, biological activities, safety and toxicology, and related patents and literature.

 

Reaxys

Reaxys contains an extensive amount of chemical information, such as chemical structures, reactions, physical properties, and visualizations.

 

SAGE Stats: Health

SAGE Stats collects statistics about the United States from a variety of sources for a range of topics, including health. Statistics about health behaviors, diseases and conditions, healthcare expenditures, insurance coverage, mortality, healthcare availability, and more are available.

 

SportDISCUS

SportDISCUS covers a variety of topics related to sports and fitness. Those relevant to biomedical sciences include sports medicine, biomechanics, and physical fitness and active living. SportDISCUS mobile interface here.

 

Sports Medicine & Education Index

The Sports Medicine and Education Index includes both scholarly and trade information. Most of the focus is on physical education, but sports medicine, kinesiology, health education, and physical therapy also have some coverage.

 

Web of Science

Web of Science indexes books, journals, and conference proceedings in multiple disciplines, including medicine and the life sciences. May be too broad for some searches, but its inclusion of interdisciplinary topics and conference materials may be useful for some searches.

 

Dictionaries

Concise Medical Dictionary

Covers terms related to drugs, techniques, equipment, treatments, healthcare organizations, medical ethics, pathology, and more.

 

Dictionary of Biology

Covers biology, biochemistry, and biophysics, with some key terms in medicine.

Dictionary of Nursing

Covers vocabulary related to nursing professions, as well as useful terms in medicine, surgery, anatomy, nutrition, pharmacology, and other related fields.

 

Dictionary of Psychology

Covers all aspects of psychology. Relevant to biomedical sciences are mental health, research methods, and neuroscience.